Selenium-72 formation via natBr(p,x) induced by 100MeV Protons: Steps towards a novel 72Se/ 72As generator system

B. Ballard; D. Wycoff; E. R. Birnbaum; K. D. John; J. W. Lenz; S. S. Jurisson; C. S. Cutler; F. M. Nortier; W. A. Taylor; M. E. Fassbender

doi:10.1016/j.apradiso.2012.01.018

Selenium-72 formation via ^natBr(p,x) induced by 100MeV Protons: Steps towards a novel ⁷²Se/ ⁷²As generator system

B. Ballard
, D. Wycoff
, E. R. Birnbaum
, K. D. John
, J. W. Lenz
, S. S. Jurisson
, C. S. Cutler
, F. M. Nortier
, W. A. Taylor
, M. E. Fassbender

Materials and Fuels Complex

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another "generator" radioisotope (Se-72, 8.5 d). A ⁷²Se/ ⁷²As generator would be the preferred mechanism for clinical utilization of ⁷²As for positron emission tomography (PET). No portable ⁷²Se/ ⁷²As generator system has been demonstrated for convenient, repeated ⁷²As elution ("milking"). In this work, we describe ⁷²Se production and recovery from irradiated NaBr targets using a 100MeV proton beam. We also introduce an ⁷²As generator principle based on ⁷²Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system.

Original language	English
Pages (from-to)	595-601
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	70
Issue number	4
DOIs	https://doi.org/10.1016/j.apradiso.2012.01.018
State	Published - Apr 2012

Keywords

Br(p,x) reaction
Dithiocarbamate synthesis
NaBr target
Se recovery
Se/As generator
Thermal analysis

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10.1016/j.apradiso.2012.01.018

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@article{e35061df2b4e4bd8ae76dc2b898883ee,

title = "Selenium-72 formation via natBr(p,x) induced by 100MeV Protons: Steps towards a novel 72Se/ 72As generator system",

abstract = "Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another {"}generator{"} radioisotope (Se-72, 8.5 d). A 72Se/ 72As generator would be the preferred mechanism for clinical utilization of 72As for positron emission tomography (PET). No portable 72Se/ 72As generator system has been demonstrated for convenient, repeated 72As elution ({"}milking{"}). In this work, we describe 72Se production and recovery from irradiated NaBr targets using a 100MeV proton beam. We also introduce an 72As generator principle based on 72Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system.",

keywords = "Br(p,x) reaction, Dithiocarbamate synthesis, NaBr target, Se recovery, Se/As generator, Thermal analysis",

author = "B. Ballard and D. Wycoff and Birnbaum, \{E. R.\} and John, \{K. D.\} and Lenz, \{J. W.\} and Jurisson, \{S. S.\} and Cutler, \{C. S.\} and Nortier, \{F. M.\} and Taylor, \{W. A.\} and Fassbender, \{M. E.\}",

note = "Funding Information: The authors would like to acknowledge the efforts of the LANL Isotope Production Facility and Hot Cell Facility personnel for their support in conducting target irradiations, target transportation, and for their general operational support. The studies described in this paper were funded by the United States Department of Energy, Office of Science via an award from The Isotope Development and Production for Research and Applications subprogram in the Office of Nuclear Physics.",

year = "2012",

month = apr,

doi = "10.1016/j.apradiso.2012.01.018",

language = "English",

volume = "70",

pages = "595--601",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Selenium-72 formation via natBr(p,x) induced by 100MeV Protons

T2 - Steps towards a novel 72Se/ 72As generator system

AU - Ballard, B.

AU - Wycoff, D.

AU - Birnbaum, E. R.

AU - John, K. D.

AU - Lenz, J. W.

AU - Jurisson, S. S.

AU - Cutler, C. S.

AU - Nortier, F. M.

AU - Taylor, W. A.

AU - Fassbender, M. E.

N1 - Funding Information: The authors would like to acknowledge the efforts of the LANL Isotope Production Facility and Hot Cell Facility personnel for their support in conducting target irradiations, target transportation, and for their general operational support. The studies described in this paper were funded by the United States Department of Energy, Office of Science via an award from The Isotope Development and Production for Research and Applications subprogram in the Office of Nuclear Physics.

PY - 2012/4

Y1 - 2012/4

N2 - Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another "generator" radioisotope (Se-72, 8.5 d). A 72Se/ 72As generator would be the preferred mechanism for clinical utilization of 72As for positron emission tomography (PET). No portable 72Se/ 72As generator system has been demonstrated for convenient, repeated 72As elution ("milking"). In this work, we describe 72Se production and recovery from irradiated NaBr targets using a 100MeV proton beam. We also introduce an 72As generator principle based on 72Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system.

AB - Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another "generator" radioisotope (Se-72, 8.5 d). A 72Se/ 72As generator would be the preferred mechanism for clinical utilization of 72As for positron emission tomography (PET). No portable 72Se/ 72As generator system has been demonstrated for convenient, repeated 72As elution ("milking"). In this work, we describe 72Se production and recovery from irradiated NaBr targets using a 100MeV proton beam. We also introduce an 72As generator principle based on 72Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system.

KW - Br(p,x) reaction

KW - Dithiocarbamate synthesis

KW - NaBr target

KW - Se recovery

KW - Se/As generator

KW - Thermal analysis

UR - https://www.scopus.com/pages/publications/84857138752

U2 - 10.1016/j.apradiso.2012.01.018

DO - 10.1016/j.apradiso.2012.01.018

M3 - Article

C2 - 22326368

AN - SCOPUS:84857138752

SN - 0969-8043

VL - 70

SP - 595

EP - 601

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 4

ER -

Selenium-72 formation via ^natBr(p,x) induced by 100MeV Protons: Steps towards a novel ⁷²Se/ ⁷²As generator system

Abstract

Keywords

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