@inproceedings{f5d3edc462984dc3a7208733f379d98c,
title = "Preparation and characterization of folate-targeted chitosan nanoparticles loaded with hydroxycamptothecin",
abstract = "FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) were prepared with a combination of emulsion-solvent evaporation and chemical crosslink method. The analysis revealed that the FA-HCPT-NPs were spherical with diameter of 255.5 ± 16.2 nm, zeta potential of + 70 mV, HCPT encapsulation efficiency of 81.2\% and loading rate of 2.5\%. X-ray powder diffraction illustrated that HCPT was buried as an amorphous form in the NPs. The release profiles of HCPT exhibited a biphasic pattern characterized by an initial burst release followed by a slower and sustained release. The results indicated that the novel FA-HCPT-NPs could be a potential drug delivery system for tumor cell-selective targeting therapy.",
keywords = "Chitosan, Folic acid, Hydroxycamptothecin (HCPT), Nanoparticle",
author = "Yixiao Wang and Zhenqing Hou and Fei Cui and Lihua Shen and Liya Xie and Zhang, \{Qi Qing\} and Yunfeng Yi",
year = "2012",
doi = "10.4028/www.scientific.net/AMR.557-559.434",
language = "English",
isbn = "9783037854570",
series = "Advanced Materials Research",
pages = "434--437",
booktitle = "Advanced Materials and Processes II",
note = "2nd International Conference on Chemical Engineering and Advanced Materials, CEAM 2012 ; Conference date: 13-07-2012 Through 15-07-2012",
}