TY - JOUR
T1 - Preparation and application of calcium phosphate nanocarriers in drug delivery
AU - Qiu, C
AU - Wu, YY
AU - Guo, QY
AU - Shi, QL
AU - Zhang, JZ
AU - Meng, YQ
AU - Xia, F
AU - Wang, JG
PY - 2022/12/15
Y1 - 2022/12/15
N2 - Calcium phosphate nanoparticles represent promising materials for drug delivery because of its favorable prop-erties, including biocompatibility, biodegradability and strong affinity for binding to nucleic acids (pDNA, siRNA, miRNA, etc.) and therapeutic drugs (cisplatin, carboplatin, paclitaxel, gefitinib, doxorubicin, etc.). Various stra-tegies to prepare the size-controllable, stable, targeting and pH-responsive CaP nanocarriers have been extensively developed as the potential candidates in clinic. This review discusses the mostly recent developments in the design of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents. Additionally, the advantage is unquestionably demonstrated and the obstacles are thoroughly examined in order to overcome future clinical issues.
AB - Calcium phosphate nanoparticles represent promising materials for drug delivery because of its favorable prop-erties, including biocompatibility, biodegradability and strong affinity for binding to nucleic acids (pDNA, siRNA, miRNA, etc.) and therapeutic drugs (cisplatin, carboplatin, paclitaxel, gefitinib, doxorubicin, etc.). Various stra-tegies to prepare the size-controllable, stable, targeting and pH-responsive CaP nanocarriers have been extensively developed as the potential candidates in clinic. This review discusses the mostly recent developments in the design of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents. Additionally, the advantage is unquestionably demonstrated and the obstacles are thoroughly examined in order to overcome future clinical issues.
KW - Application
KW - Calcium phosphate
KW - Drug delivery
KW - Nanocarrier
KW - Preparation
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_id&SrcAuth=WosAPI&KeyUT=WOS:000907556300006&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1016/j.mtbio.2022.100501
DO - 10.1016/j.mtbio.2022.100501
M3 - Article
C2 - 36466957
SN - 2590-0064
VL - 17
JO - Materials Today Bio
JF - Materials Today Bio
M1 - 100501
ER -