Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Cam-CAN

doi:10.1038/s41467-020-15410-w

Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Cam-CAN

Nuclear Safety & Regulatory Research

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105 Scopus citations

Abstract

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.

Original language	English
Article number	1712
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-15410-w
State	Published - Dec 1 2020

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10.1038/s41467-020-15410-w

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@article{e7880f407ab14b95b4237487be3bea6f,

title = "Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences",

abstract = "The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.",

author = "Cam-CAN and Liu, \{Kathy Y.\} and Kievit, \{Rogier A.\} and Tsvetanov, \{Kamen A.\} and Betts, \{Matthew J.\} and Emrah D{\"u}zel and Rowe, \{James B.\} and Tyler, \{Lorraine K.\} and Carol Brayne and Bullmore, \{Edward T.\} and Calder, \{Andrew C.\} and Rhodri Cusack and Tim Dalgleish and John Duncan and Henson, \{Richard N.\} and Matthews, \{Fiona E.\} and Marslen-Wilson, \{William D.\} and Shafto, \{Meredith A.\} and Karen Campbell and Teresa Cheung and Simon Davis and Linda Geerligs and Anna McCarrey and Abdur Mustafa and Darren Price and David Samu and Taylor, \{Jason R.\} and Matthias Treder and Belle, \{Janna van\} and Nitin Williams and Lauren Bates and Tina Emery and Sharon Erzin{\c c}lioglu and Andrew Gadie and Sofia Gerbase and Stanimira Georgieva and Claire Hanley and Beth Parkin and David Troy and Tibor Auer and Marta Correia and Lu Gao and Emma Green and Rafael Henriques and Jodie Allen and Gillian Amery and Liana Amunts and Anne Barcroft and Amanda Castle and Cheryl Dias and Jonathan Dowrick",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41467-020-15410-w",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

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TY - JOUR

T1 - Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

AU - Cam-CAN

AU - Liu, Kathy Y.

AU - Kievit, Rogier A.

AU - Tsvetanov, Kamen A.

AU - Betts, Matthew J.

AU - Düzel, Emrah

AU - Rowe, James B.

AU - Tyler, Lorraine K.

AU - Brayne, Carol

AU - Bullmore, Edward T.

AU - Calder, Andrew C.

AU - Cusack, Rhodri

AU - Dalgleish, Tim

AU - Duncan, John

AU - Henson, Richard N.

AU - Matthews, Fiona E.

AU - Marslen-Wilson, William D.

AU - Shafto, Meredith A.

AU - Campbell, Karen

AU - Cheung, Teresa

AU - Davis, Simon

AU - Geerligs, Linda

AU - McCarrey, Anna

AU - Mustafa, Abdur

AU - Price, Darren

AU - Samu, David

AU - Taylor, Jason R.

AU - Treder, Matthias

AU - Belle, Janna van

AU - Williams, Nitin

AU - Bates, Lauren

AU - Emery, Tina

AU - Erzinçlioglu, Sharon

AU - Gadie, Andrew

AU - Gerbase, Sofia

AU - Georgieva, Stanimira

AU - Hanley, Claire

AU - Parkin, Beth

AU - Troy, David

AU - Auer, Tibor

AU - Correia, Marta

AU - Gao, Lu

AU - Green, Emma

AU - Henriques, Rafael

AU - Allen, Jodie

AU - Amery, Gillian

AU - Amunts, Liana

AU - Barcroft, Anne

AU - Castle, Amanda

AU - Dias, Cheryl

AU - Dowrick, Jonathan

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.

AB - The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.

UR - https://www.scopus.com/pages/publications/85083071799

U2 - 10.1038/s41467-020-15410-w

DO - 10.1038/s41467-020-15410-w

M3 - Article

C2 - 32249849

AN - SCOPUS:85083071799

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1712

ER -

Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

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