@article{29037777a85d48e6b48e8aa5a3603b6c,
title = "High purity 47Sc production using high-energy photons and natural vanadium targets",
abstract = "Scandium-47 (47Sc) is of high value for targeted radiotherapy and theranostics; we report a novel, cost-effective approach to produce high-purity 47Sc via photonuclear reactions with natural vanadium. Irradiation at 20 MeV photon end-point energy produces >99.998% pure 47Sc, while irradiation at 38 MeV produces 98.8 ± 1.6% pure 47Sc. Experimental data suggest producing greater than 100 mCi (3700 MBq) of 47Sc using this approach may be feasible. Future research into refinement and scale-up to support pre-clinical research is recommended.",
keywords = "Bremsstrahlung, Cancer therapy, Isotope production, Photonuclear, Sc-47, Theranostics",
author = "Snow, {Mathew S.} and Ari Foley and Ward, {Jessica L.} and Kinlaw, {Mathew T.} and Jon Stoner and Carney, {Kevin P.}",
note = "Funding Information: The authors would like to thank Dr. Steven Hartenstein for his advice and guidance with this work, Dr. Erin Searcy and Dr. Marianne Walck for their technical comments and direction with regards to funding support, Dr. Edna Cardenas and Dr. Brian Bucher for their technical advice and reviews of the data and Mr. Hayden Town for assistance with technical editing. The authors also want to thank the Idaho Accelerator Center staff, Kevin Folkman, Chad O'Neil, Brian Berls, and John Longley for their help in performing the experiments. This work was supported through the Idaho National Laboratory Directed Research & Development (LDRD) Program under DOE Idaho Operations Office Contract DE-AC07-05ID14517 . Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe on privately owned rights. References herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government or any agency thereof. Views and opinions of the authors expressed herein do not necessarily reflect those of the U.S. Government or any agency thereof. This research also made use of the resources at the High Performance Computing Center at Idaho National Laboratory , which is supported by the Office of Nuclear Energy of the U.S. Department of Energy and the Nuclear Science User Facilities under Contract No. DE-AC07-05ID14517 . Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = dec,
doi = "10.1016/j.apradiso.2021.109934",
language = "English",
volume = "178",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier Ltd",
}