TY - JOUR
T1 - Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications
AU - Sana, SS
AU - Vadde, R
AU - Kumar, R
AU - Arla, SK
AU - Somala, AR
AU - Rao, KSVK
AU - Boya, VKN
AU - Zhijun, Z
AU - Mondal, K
AU - Mamidi, N
N1 - Funding Information:
All authors are thankful to Yogi Vemana University, India, and the North University of China, China, University of Nebraska Medical Center and Idaho National Laboratory, USA, and Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico.
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.
AB - Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.
KW - Biomedical
KW - Biosynthesize
KW - Drug delivery
KW - Green synthesis
KW - Metal oxide nanoparticles
KW - Zinc oxide nanoparticles
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_id&SrcAuth=WosAPI&KeyUT=WOS:000926328300001&DestLinkType=FullRecord&DestApp=WOS
UR - https://www.scopus.com/pages/publications/85146870647
UR - https://www.mendeley.com/catalogue/04ab1830-8358-3b5a-a51b-416c5d57d9a9/
U2 - 10.1016/j.jddst.2023.104186
DO - 10.1016/j.jddst.2023.104186
M3 - Article
SN - 1773-2247
VL - 80
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 104186
ER -