Determination of CMPO using HPLC-UV

Gracy Elias; Gary S. Groenewold; Bruce J. Mincher; Stephen P. Mezyk

doi:10.1016/j.chroma.2012.04.047

Determination of CMPO using HPLC-UV

Gracy Elias, Gary S. Groenewold, Bruce J. Mincher, Stephen P. Mezyk

Energy & Environmental Science & Technology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Octyl(phenyl)- N,. N-diisobutylcarbamoylmethylphosphine oxide (CMPO) is an extractant proposed for selective separation of radionuclide metals from used nuclear fuel solutions using solvent extraction. Radiolysis reactions can degrade CMPO and reduce separation performance and hence methods for measuring the concentration of CMPO are needed. A novel high performance liquid chromatography (HPLC) method was developed for measuring CMPO in dodecane that featured a low pH buffer, octanol as a co-solvent with 2-propanol, and ultraviolet (UV) detection. Validation data indicated that the HPLC-UV method for CMPO determination provided good linearity, sensitivity, accuracy and precision. Method performance was evaluated using CMPO samples that had undergone radiolysis, and the results showed a decrease in CMPO concentration and the appearance of degradation products. The degradation products were identified using electrospray ionization mass spectrometry, which also showed formation of CMPO-nitric acid complexes that account for the apparent loss of CMPO in an acidic environment, independent of irradiation.

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Journal of Chromatography A
Volume	1243
DOIs	https://doi.org/10.1016/j.chroma.2012.04.047
State	Published - Jun 22 2012

Keywords

CMPO
Electrospray ionization mass spectrometry
High performance liquid chromatography
Ligands
Radiolysis
Radionuclides

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10.1016/j.chroma.2012.04.047

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@article{c8420710f16b4842af265bf24aef5194,

title = "Determination of CMPO using HPLC-UV",

abstract = "Octyl(phenyl)- N,. N-diisobutylcarbamoylmethylphosphine oxide (CMPO) is an extractant proposed for selective separation of radionuclide metals from used nuclear fuel solutions using solvent extraction. Radiolysis reactions can degrade CMPO and reduce separation performance and hence methods for measuring the concentration of CMPO are needed. A novel high performance liquid chromatography (HPLC) method was developed for measuring CMPO in dodecane that featured a low pH buffer, octanol as a co-solvent with 2-propanol, and ultraviolet (UV) detection. Validation data indicated that the HPLC-UV method for CMPO determination provided good linearity, sensitivity, accuracy and precision. Method performance was evaluated using CMPO samples that had undergone radiolysis, and the results showed a decrease in CMPO concentration and the appearance of degradation products. The degradation products were identified using electrospray ionization mass spectrometry, which also showed formation of CMPO-nitric acid complexes that account for the apparent loss of CMPO in an acidic environment, independent of irradiation.",

keywords = "CMPO, Electrospray ionization mass spectrometry, High performance liquid chromatography, Ligands, Radiolysis, Radionuclides",

author = "Gracy Elias and Groenewold, {Gary S.} and Mincher, {Bruce J.} and Mezyk, {Stephen P.}",

note = "Funding Information: This research was funded by the U.S. DOE Office of Nuclear Energy, Fuel Cycle Research and Development Program , under DOE Idaho Operations Office contract DE-AC07-99ID13727.",

year = "2012",

month = jun,

day = "22",

doi = "10.1016/j.chroma.2012.04.047",

language = "English",

volume = "1243",

pages = "47--52",

journal = "Journal of Chromatography A",

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T1 - Determination of CMPO using HPLC-UV

AU - Elias, Gracy

AU - Groenewold, Gary S.

AU - Mincher, Bruce J.

AU - Mezyk, Stephen P.

N1 - Funding Information: This research was funded by the U.S. DOE Office of Nuclear Energy, Fuel Cycle Research and Development Program , under DOE Idaho Operations Office contract DE-AC07-99ID13727.

PY - 2012/6/22

Y1 - 2012/6/22

N2 - Octyl(phenyl)- N,. N-diisobutylcarbamoylmethylphosphine oxide (CMPO) is an extractant proposed for selective separation of radionuclide metals from used nuclear fuel solutions using solvent extraction. Radiolysis reactions can degrade CMPO and reduce separation performance and hence methods for measuring the concentration of CMPO are needed. A novel high performance liquid chromatography (HPLC) method was developed for measuring CMPO in dodecane that featured a low pH buffer, octanol as a co-solvent with 2-propanol, and ultraviolet (UV) detection. Validation data indicated that the HPLC-UV method for CMPO determination provided good linearity, sensitivity, accuracy and precision. Method performance was evaluated using CMPO samples that had undergone radiolysis, and the results showed a decrease in CMPO concentration and the appearance of degradation products. The degradation products were identified using electrospray ionization mass spectrometry, which also showed formation of CMPO-nitric acid complexes that account for the apparent loss of CMPO in an acidic environment, independent of irradiation.

AB - Octyl(phenyl)- N,. N-diisobutylcarbamoylmethylphosphine oxide (CMPO) is an extractant proposed for selective separation of radionuclide metals from used nuclear fuel solutions using solvent extraction. Radiolysis reactions can degrade CMPO and reduce separation performance and hence methods for measuring the concentration of CMPO are needed. A novel high performance liquid chromatography (HPLC) method was developed for measuring CMPO in dodecane that featured a low pH buffer, octanol as a co-solvent with 2-propanol, and ultraviolet (UV) detection. Validation data indicated that the HPLC-UV method for CMPO determination provided good linearity, sensitivity, accuracy and precision. Method performance was evaluated using CMPO samples that had undergone radiolysis, and the results showed a decrease in CMPO concentration and the appearance of degradation products. The degradation products were identified using electrospray ionization mass spectrometry, which also showed formation of CMPO-nitric acid complexes that account for the apparent loss of CMPO in an acidic environment, independent of irradiation.

KW - CMPO

KW - Electrospray ionization mass spectrometry

KW - High performance liquid chromatography

KW - Ligands

KW - Radiolysis

KW - Radionuclides

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DO - 10.1016/j.chroma.2012.04.047

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VL - 1243

SP - 47

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JO - Journal of Chromatography A

JF - Journal of Chromatography A

ER -

Determination of CMPO using HPLC-UV

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